Volume 19; 2024

Research

The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer

Tian Tian, Yahui Leng, Bingbing Tang, Xiaoxia Dong, Qiulei Ren, Jingyin Liang, Tianhui Liu, Yanni Liu, Wenxiao Feng, Song Liu, Yang Zhou, Hongyan Zhao, Li Shen

Biol Direct. 2024; 19: 1. Published online 2024 Jan 2. doi: 10.1186/s13062-023-00448-9

PMCID:: PMC10759362

Article PDF–18M

DTX2 promotes glioma development via regulation of HLTF

Ren Li, Yang Chen, Biao Yang, Ziao Li, Peize Li, Yu Chen, Jiayu Li, Jianhang He, Yongqiang Wu, Yanqi Sun, Xiaogang Wang, Xiaolong Guo, Wenju Zhang, Yuanli Zhao, Geng Guo

Biol Direct. 2024; 19: 2. Published online 2024 Jan 2. doi: 10.1186/s13062-023-00447-w

PMCID:: PMC10759338

Article PDF–6.0M

GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy

Lin Li, Jinlong Tang, Bin Cao, Qiang Xu, Shouying Xu, Chao Lin, Chao Tang

Biol Direct. 2024; 19: 3. Published online 2024 Jan 2. doi: 10.1186/s13062-023-00449-8

PMCID:: PMC10759669

Article PDF–10M

Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma

Kunyuan Wang, Qianting Lu, Yufeng Luo, Ganxiang Yu, Zhilei Wang, Jiaen Lin, Zhenlin Tan, Yueqiong Lao, Shiming Liu, Hui Yang

Biol Direct. 2024; 19: 4. Published online 2024 Jan 2. doi: 10.1186/s13062-023-00442-1

PMCID:: PMC10759731

Article PDF–7.6M

Risk assessment of transgender people: implementation of a demasculinizing–feminizing rodent model including the evaluation of thyroid homeostasis

Alessia Tammaro, Gabriele Lori, Andrea Martinelli, Luigia Cancemi, Roberta Tassinari, Francesca Maranghi

Biol Direct. 2024; 19: 5. Published online 2024 Jan 2. doi: 10.1186/s13062-023-00450-1

Correction in:: Biol Direct. 2024; 19: 12.

PMCID:: PMC10759629

Article PDF–2.6M

Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy

Qiao Zhou, Jiamin Zhang, Jingsong Zhang, Simin Liang, Duo Cai, Han Xiao, Yu Zhu, Wenqiong Xiang, Fernando Rodrigues-Lima, Jianxiang Chi, Fabien Guidez, Li Wang

Biol Direct. 2024; 19: 6. Published online 2024 Jan 4. doi: 10.1186/s13062-023-00451-0

PMCID:: PMC10768477

Article PDF–14M

PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1

Yuanliang Zheng, Lixiang Zhang, Kangliang Zhang, Shenghao Wu, Chichao Wang, Risheng Huang, Hongli Liao

Biol Direct. 2024; 19: 7. Published online 2024 Jan 17. doi: 10.1186/s13062-024-00452-7

PMCID:: PMC10792809

Article PDF–7.1M

PICLS with human cells is the first high throughput screening method for identifying novel compounds that extend lifespan

Mohammad Alfatah, Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng, Frank Eisenhaber

Biol Direct. 2024; 19: 8. Published online 2024 Jan 23. doi: 10.1186/s13062-024-00455-4

PMCID:: PMC10804585

Article PDF–2.5M

Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway

Lianglei Jiang, Ting Fang, Tingting Hu, Jun Feng, Pengfei Yan

Biol Direct. 2024; 19: 9. Published online 2024 Jan 24. doi: 10.1186/s13062-023-00443-0

PMCID:: PMC10807173

Article PDF–2.3M

MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain

Yuqi Liu, Lijuan Wang, Chengcheng Zhou, Yuan Yuan, Bin Fang, Kaimei Lu, Fangxia Xu, Lianhua Chen, Lina Huang

Biol Direct. 2024; 19: 10. Published online 2024 Jan 24. doi: 10.1186/s13062-023-00434-1

PMCID:: PMC10807213

Article PDF–2.7M

Effect of glycosylation on the affinity of the MTB protein Ag85B for specific antibodies: towards the design of a dual-acting vaccine against tuberculosis

Roberta Bernardini, Sara Tengattini, Zhihao Li, Luciano Piubelli, Teodora Bavaro, Anamaria Bianca Modolea, Maurizio Mattei, Paola Conti, Stefano Marini, Yongmin Zhang, Loredano Pollegioni, Caterina Temporini, Marco Terreni

Biol Direct. 2024; 19: 11. Published online 2024 Jan 25. doi: 10.1186/s13062-024-00454-5

PMCID:: PMC10809592

Article PDF–1.6M

USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1

Qingsong Wu, Yuanyuan Qiu, Jinhui Guo, Zibo Yuan, Yingnan Yang, Qingwei Zhu, Zhe Zhang, Junwei Guo, Yanfang Wu, Junyu Zhang, Dongsheng Huang, Kangsheng Tu, Xiaoge Hu

Biol Direct. 2024; 19: 13. Published online 2024 Feb 2. doi: 10.1186/s13062-024-00456-3

PMCID:: PMC10837946

Article PDF–3.2M

Tissue-specific roles of peroxisomes revealed by expression meta-analysis

Matthias Plessner, Leonie Thiele, Julia Hofhuis, Sven Thoms

Biol Direct. 2024; 19: 14. Published online 2024 Feb 16. doi: 10.1186/s13062-024-00458-1

PMCID:: PMC10873952

Article PDF–7.7M

RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2

Yarong Guo, Bao Chai, Hezhao Zhang, Xinhao Chai, Yan Chen, Jun Xu, Liwei Qin, Yuting Chai

Biol Direct. 2024; 19: 15. Published online 2024 Feb 23. doi: 10.1186/s13062-024-00459-0

PMCID:: PMC10885466

Article PDF–8.7M

RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination

Chengshuo Zhang, Yu Wang, Gang Wu, Ning Sun, Han Bai, Xuejian Li, Shuai Han, Haonan Zhou, Ruizhao Qi, Jialin Zhang

Biol Direct. 2024; 19: 16. Published online 2024 Feb 23. doi: 10.1186/s13062-024-00453-6

PMCID:: PMC10885515

Article PDF–8.9M

Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway

Du Shen, Shaosan Kang

Biol Direct. 2024; 19: 17. Published online 2024 Feb 26. doi: 10.1186/s13062-024-00461-6

Correction in:: Biol Direct. 2024; 19: 27.

PMCID:: PMC10898125

Article PDF–12M

Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway

Zhihuai Wang, Yinjie Zhang, Yuhang Shen, Haiyang Zhou, Yuan Gao, Chunfu Zhu, Xihu Qin

Biol Direct. 2024; 19: 18. Published online 2024 Feb 28. doi: 10.1186/s13062-024-00460-7

PMCID:: PMC10903047

Article PDF–12M

PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA

Zhiwei Chang, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao, Dandan Yu, Xiaolei Liu, Jing Li, Yanru Qin

Biol Direct. 2024; 19: 19. Published online 2024 Mar 1. doi: 10.1186/s13062-023-00440-3

PMCID:: PMC10905922

Article PDF–3.1M

Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma

Shiliang Cheng, Chunguang Li, Lu Liu, Xinli Liu, Meng Li, Jinhua Zhuo, Jue Wang, Wen Zheng, Zhongmin Wang

Biol Direct. 2024; 19: 20. Published online 2024 Mar 7. doi: 10.1186/s13062-023-00446-x

PMCID:: PMC10918934

Article PDF–12M

Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway

Lifang He, Chuanghong She, Sen Jiang, Zhaochang Qi, Zihao Deng, Likeng Ji, Yukun Cui, Jundong Wu

Biol Direct. 2024; 19: 21. Published online 2024 Mar 8. doi: 10.1186/s13062-024-00464-3

PMCID:: PMC10921784

Article PDF–8.4M

Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance

Kaikai Qiao, Qingtao Zeng, Jiaoyan Lv, Lingling Chen, Juxin Hao, Ding Wang, Qifeng Ma, Shuli Fan

Biol Direct. 2024; 19: 22. Published online 2024 Mar 14. doi: 10.1186/s13062-024-00465-2

PMCID:: PMC10938729

Article PDF–7.7M

Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling

Leiyi Zhang, Xiaoxiang Gong, Juan Tan, Rongsen Zhang, Mingxia Li, Cong Liu, Chenhao Wu, Xiaojing Li

Biol Direct. 2024; 19: 23. Published online 2024 Mar 18. doi: 10.1186/s13062-024-00462-5

PMCID:: PMC10946149

Article PDF–4.4M

LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4

Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou, Chuanzhao Zhang

Biol Direct. 2024; 19: 24. Published online 2024 Mar 19. doi: 10.1186/s13062-024-00463-4

PMCID:: PMC10949730

Article PDF–11M

Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p

Ying Zhang, Yizhou Zhan, Zhaoyong Liu, Huancheng Guo, Dongchen Liu, Chuangzhen Chen

Biol Direct. 2024; 19: 25. Published online 2024 Apr 3. doi: 10.1186/s13062-024-00466-1

PMCID:: PMC10988859

Article PDF–17M

Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity

Mario Villa-González, Marina Rubio, Gerardo Martín-López, Paula R. Mallavibarrena, Laura Vallés-Saiz, Denis Vivien, Francisco Wandosell, Maria José Pérez-Álvarez

Biol Direct. 2024; 19: 26. Published online 2024 Apr 6. doi: 10.1186/s13062-024-00470-5

PMCID:: PMC10999095

Article PDF–13M

ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway

Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu, Weichun Guo

Biol Direct. 2024; 19: 28. Published online 2024 Apr 22. doi: 10.1186/s13062-024-00472-3

PMCID:: PMC11034355

Article PDF–15M

Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging

Lin-Lin Hu, Mei-Hua Liao, Ya-Xi Liu, Chun-Hua Xing, Lan-Lan Nong, Feng-Lian Yang, Shao-Chen Sun

Biol Direct. 2024; 19: 29. Published online 2024 Apr 23. doi: 10.1186/s13062-024-00471-4

PMCID:: PMC11036640

Article PDF–11M

Biomimetic peroxidase MOF-Fe promotes bone defect repair by inhibiting TfR2 and activating the BMP2 pathway

Yaxin Xue, Wei Xu, Danyang Zhao, Zijing Du, Hao Jiang, Hao Lv, Dong Zhang, Zhencheng Yu, Yi Cao, Dong Han

Biol Direct. 2024; 19: 30. Published online 2024 Apr 23. doi: 10.1186/s13062-024-00473-2

PMCID:: PMC11036606

Article PDF–11M

OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1

Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo, Qiuran Xu

Biol Direct. 2024; 19: 31. Published online 2024 Apr 24. doi: 10.1186/s13062-024-00475-0

PMCID:: PMC11041014

Article PDF–8.9M

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang, Yan Ding

Biol Direct. 2024; 19: 32. Published online 2024 Apr 29. doi: 10.1186/s13062-024-00477-y

PMCID:: PMC11057147

Article PDF–2.7M

Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight

Mingqi Zhou, Alberto Riva, Marie-Pierre L. Gauthier, Michael P. Kladde, Robert J. Ferl, Anna-Lisa Paul

Biol Direct. 2024; 19: 33. Published online 2024 Apr 30. doi: 10.1186/s13062-024-00476-z

PMCID:: PMC11059628

Article PDF–7.7M

LncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer

Jia Cao, Yicheng Yang, Bensong Duan, Haibin Zhang, Qinwei Xu, Junyi Han, Bing Lu

Biol Direct. 2024; 19: 34. Published online 2024 May 2. doi: 10.1186/s13062-024-00468-z

PMCID:: PMC11064384

Article PDF–15M

UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells

Bo Yang, Weihua Chen, Tianyi Tao, Jun Zhang, Dehui Kong, Jidong Hao, Chao Yu, Guoqiang Liao, Hua Gong

Biol Direct. 2024; 19: 35. Published online 2024 May 7. doi: 10.1186/s13062-024-00469-y

PMCID:: PMC11075218

Article PDF–7.5M

CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1α-mediated glycometabolism alteration

Yiting Geng, Xiao Zheng, Dachuan Zhang, Shanshan Wei, Jun Feng, Wei Wang, Luo Zhang, Changping Wu, Wenwei Hu

Biol Direct. 2024; 19: 36. Published online 2024 May 7. doi: 10.1186/s13062-024-00478-x

PMCID:: PMC11075259

Article PDF–10M

Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor suppressor in clear cell renal cell carcinoma

Qingpeng Xie, Bin Hu, Haosong Li

Biol Direct. 2024; 19: 37. Published online 2024 May 11. doi: 10.1186/s13062-024-00480-3

PMCID:: PMC11088781

Article PDF–7.5M

Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles

Konrad Grützmann, Karsten Salomo, Alexander Krüger, Andrea Lohse-Fischer, Kati Erdmann, Michael Seifert, Gustavo Baretton, Daniela Aust, Doreen William, Evelin Schröck, Christian Thomas, Susanne Füssel

Biol Direct. 2024; 19: 38. Published online 2024 May 13. doi: 10.1186/s13062-024-00467-0