Skip to main content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Volume 45(5);  2024 May

Articles from this journal are generally available in PMC after a 12-month delay (embargo); however, the delay may vary at the discretion of the publisher.

Articles

Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models
Xin-jie Guan, Zhi-qiang Deng, Jia Liu, Cheng-fu Su, Benjamin Chun-Kit Tong, Zhou Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Yu-xuan Kan, Ke-jia Lu, Carol Pui-Kei Chu, Rong-biao Pi, King-ho Cheung, Ashok Iyaswamy, Ju-xian Song, Min Li
Acta Pharmacol Sin. 2024 May; 45(5): 900–913. Published online 2024 Jan 15. doi: 10.1038/s41401-023-01197-1
PMCID:
PMC11053156
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients
Zhu-wei Miao, Nuo Wang, Wen-jun Hu, Si-li Zheng, Dong-sheng Wang, Fu-qiang Chang, Zhi Wang, Jia-sheng Tian, Xiao-hui Dong, Tao Wu, Chao-yu Miao
Acta Pharmacol Sin. 2024 May; 45(5): 914–925. Published online 2024 Jan 22. doi: 10.1038/s41401-023-01204-5
PMCID:
PMC11053017
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Desloratadine alleviates ALS-like pathology in hSOD1G93A mice via targeting 5HTR2A on activated spinal astrocytes
Jian Lu, An-xu He, Zhuo-ying Jin, Meng Zhang, Zhong-xin Li, Fan Zhou, Lin Ma, Hong-ming Jin, Jia-ying Wang, Xu Shen
Acta Pharmacol Sin. 2024 May; 45(5): 926–944. Published online 2024 Jan 29. doi: 10.1038/s41401-023-01223-2
PMCID:
PMC11053015
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats
Ruo-song Chen, Jing Liu, Yu-jun Wang, Kuan Ning, Jing-gen Liu, Zhi-qiang Liu
Acta Pharmacol Sin. 2024 May; 45(5): 945–958. Published online 2024 Feb 7. doi: 10.1038/s41401-024-01229-4
PMCID:
PMC11053033
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching
Shi-chun Shen, Jie Xu, Cheng Cheng, Xin-jian Xiang, Bao-yu Hong, Meng Zhang, Chen Gong, Li-kun Ma
Acta Pharmacol Sin. 2024 May; 45(5): 959–974. Published online 2024 Jan 15. doi: 10.1038/s41401-023-01222-3
PMCID:
PMC11053127
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Endothelial cell Orai1 is essential for endothelium-dependent contraction of mouse carotid arteries in normotensive and hypertensive mice
Xiao Li, Zhen-chuan Lei, Chun Yin Lo, Tsz Yau Jan, Chi Wai Lau, Xiao-qiang Yao
Acta Pharmacol Sin. 2024 May; 45(5): 975–987. Published online 2024 Jan 26. doi: 10.1038/s41401-024-01227-6
PMCID:
PMC11053128
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways
Yan-ni Zhao, Zhou-di Liu, Tao Yan, Ting-xin Xu, Tian-yang Jin, Yong-sheng Jiang, Wei Zuo, Kwang Youl Lee, Li-jiang Huang, Yi Wang
Acta Pharmacol Sin. 2024 May; 45(5): 988–1001. Published online 2024 Jan 26. doi: 10.1038/s41401-024-01226-7
PMCID:
PMC11053141
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis
Ting-lv Fu, Guo-rui Li, Dong-hang Li, Ru-yuan He, Bo-hao Liu, Rui Xiong, Chen-zhen Xu, Zi-long Lu, Cong-kuan Song, Hong-liang Qiu, Wen-jie Wang, Shi-shi Zou, Ke Yi, Ning Li, Qing Geng
Acta Pharmacol Sin. 2024 May; 45(5): 1002–1018. Published online 2024 Jan 15. doi: 10.1038/s41401-023-01202-7
PMCID:
PMC11053064
Currently embargoed: Free in PMC on May 1, 2025; PubMed
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice
Fu-wen Zuo, Zhi-yong Liu, Ming-wei Wang, Jun-yao Du, Peng-zhong Ding, Hao-ran Zhang, Wei Tang, Yu Sun, Xiao-jie Wang, Yan Zhang, Yu-sheng Xie, Ji-chao Wu, Min Liu, Zi-ying Wang, Fan Yi
Acta Pharmacol Sin. 2024 May; 45(5): 1019–1031. Published online 2024 Jan 16. doi: 10.1038/s41401-023-01213-4
PMCID:
PMC11053164
Currently embargoed: Free in PMC on May 1, 2025; PubMed
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis
Yun-yang Qiao, Jia-ling Ji, Wei-ling Hou, Gao-ting Qu, Shan-wen Li, Xing-yue Li, Ran Jin, Yin-fang Li, Hui-min Shi, Ai-qing Zhang
Acta Pharmacol Sin. 2024 May; 45(5): 1032–1043. Published online 2024 Jan 29. doi: 10.1038/s41401-024-01228-5
PMCID:
PMC11053026
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1
Han Zhang, Fei Xie, Xiao-ya Yuan, Xin-tong Dai, Yun-feng Tian, Ming-ming Sun, Si-qi Yu, Jia-you Cai, Bin Sun, Wei-cheng Zhang, Chang-liang Shan
Acta Pharmacol Sin. 2024 May; 45(5): 1044–1059. Published online 2024 Feb 7. doi: 10.1038/s41401-024-01231-w
PMCID:
PMC11053100
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer
Ling-bing Li, Ling-xiao Yang, Lei Liu, Fan-rong Liu, Alex H. Li, Yi-lin Zhu, Hao Wen, Xia Xue, Zhong-xian Tian, Hong Sun, Pei-chao Li, Xiao-gang Zhao
Acta Pharmacol Sin. 2024 May; 45(5): 1060–1076. Published online 2024 Jan 16. doi: 10.1038/s41401-023-01219-y
PMCID:
PMC11053095
Article PDF–9.0M
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation
Chen Cheng, Chao Ren, Mu-zi Li, Yi-hui Liu, Ren-qi Yao, Yang Yu, Xuan Yu, Jian-li Wang, Li-xue Wang, Yu-chun Leng, Hui Zhang, Fei-fei Du, Ning Dong, Feng-qing Wang, Yao Wu, Fang Xu, Xiao-mei Zhu, Gui-ping Zhang, Kai Dong, Si Liu, Xiao-qing Yao, Chuan Li, Yong-ming Yao
Acta Pharmacol Sin. 2024 May; 45(5): 1077–1092. Published online 2024 Jan 24. doi: 10.1038/s41401-023-01224-1
PMCID:
PMC11053071
Currently embargoed: Free in PMC on May 1, 2025; PubMed

Review Articles

Structural and functional insights into the epigenetic regulator MRG15
Nan Jiang, Yong-bo Li, Jia-yu Jin, Jie-yu Guo, Qiu-rong Ding, Dan Meng, Xiu-ling Zhi
Acta Pharmacol Sin. 2024 May; 45(5): 879–889. Published online 2024 Jan 8. doi: 10.1038/s41401-023-01211-6
PMCID:
PMC11053006
Currently embargoed: Free in PMC on May 1, 2025; PubMed
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
Xiao-yu Ma, Man-man Chen, Ling-hua Meng
Acta Pharmacol Sin. 2024 May; 45(5): 890–899. Published online 2024 Jan 4. doi: 10.1038/s41401-023-01210-7
PMCID:
PMC11053103
Currently embargoed: Free in PMC on May 1, 2025; PubMed

Correction

Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells
Yue-hong Chen, Hao Lv, Ning Shen, Xiao-min Wang, Shuai Tang, Bing Xiong, Jian Ding, Mei-yu Geng, Min Huang
Acta Pharmacol Sin. 2024 May; 45(5): 1093–1094. Published online 2024 Jan 16. doi: 10.1038/s41401-023-01208-1
Corrects:
Acta Pharmacol Sin. 2020 Feb; 41(2): 270–277.
PMCID:
PMC11053107
Correction PDF–487K
Articles from Acta Pharmacologica Sinica are provided here courtesy of Nature Publishing Group