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    CCT1 phosphorylcholine cytidylyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817786, updated on 7-Sep-2023

    Summary

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    Gene symbol
    CCT1
    Gene description
    phosphorylcholine cytidylyltransferase
    Primary source
    Araport:AT2G32260
    Locus tag
    AT2G32260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCCT1; phosphorylcholine cytidylyltransferase; T32F6.22; T32F6_22
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    Genomic context

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    See CCT1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (13697457..13700648)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene early endosome antigen Neighboring gene FAR1-related sequence 2 Neighboring gene ncRNA Neighboring gene zinc transporter 3 precursor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis CTP:phosphocholine cytidylyltransferase 1 is phosphorylated and inhibited by sucrose nonfermenting 1-related protein kinase 1 (SnRK1). Caldo KMP, et al. J Biol Chem, 2019 Oct 25. PMID 31439667, Free PMC Article
    2. Isozyme-specific modes of activation of CTP:phosphorylcholine cytidylyltransferase in Arabidopsis thaliana at low temperature. Inatsugi R, et al. Plant Cell Physiol, 2009 Oct. PMID 19667100
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SnRK1 mediates the phosphorylation and concomitant inhibition of AtCCT1.
      Title: Arabidopsis CTP:phosphocholine cytidylyltransferase 1 is phosphorylated and inhibited by sucrose nonfermenting 1-related protein kinase 1 (SnRK1).
    2. The CDP-choline pathway of A. thaliana is up-regulated at low temperature via isogene-specific modes: enhanced expression of CCT2 and post-translational activation/inactivation of CCT1 in membranes.
      Title: Isozyme-specific modes of activation of CTP:phosphorylcholine cytidylyltransferase in Arabidopsis thaliana at low temperature.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    NM_001336383.1
    NM_128785.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables choline-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylcholine cytidylyltransferase
    NP_180785.1
    • phosphorylcholine cytidylyltransferase (CCT1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Cytidyltransferase-related (InterPro:IPR004821), Cytidylyltransferase (InterPro:IPR004820); BEST Arabidopsis thaliana protein match is: phosphorylcholine cytidylyltransferase2 (TAIR:AT4G15130.1); Has 2466 Blast hits to 2109 proteins in 632 species: Archae - 27; Bacteria - 791; Metazoa - 538; Fungi - 333; Plants - 250; Viruses - 5; Other Eukaryotes - 522 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13697457..13700648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128785.3 → NP_180785.1  phosphorylcholine cytidylyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180785.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZV56
      UniProtKB/TrEMBL
      A0A178VQG6, A0A2K8ETV8, A0A384KL63, Q42555
      Conserved Domains (1) summary
      PLN02413
      Location:26 → 293
      PLN02413; choline-phosphate cytidylyltransferase

    2. NM_001336383.1 → NP_001323485.1  phosphorylcholine cytidylyltransferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AXC2, Q42555
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZV56.1

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