NTS neurotensin [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTSprovided by HGNC
Official Full Name: neurotensinprovided by HGNC
Primary source: HGNC:HGNC:8038
See related: Ensembl:ENSG00000133636 MIM:162650; AllianceGenome:HGNC:8038
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NN; NT; NT/N; NTS1; NMN-125
Summary: This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
Expression: Biased expression in small intestine (RPKM 86.5), stomach (RPKM 27.6) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 12q21.31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (85874295..85882992)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (85854932..85863806)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (86268073..86276770)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurotensin contributes to cholestatic liver disease potentially modulating matrix metalloprotease-7.
Title: Neurotensin contributes to cholestatic liver disease potentially modulating matrix metalloprotease-7.
Expression of Neurotensin and Its Receptors Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
Title: Expression of Neurotensin and Its Receptors Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
Neurotensin Gene rs2234762 C>G Variant Associates with Reduced Circulating Pro-NT Levels and Predicts Lower Insulin Resistance in Overweight/Obese Children.
Title: Neurotensin Gene rs2234762 C>G Variant Associates with Reduced Circulating Pro-NT Levels and Predicts Lower Insulin Resistance in Overweight/Obese Children.
Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature.
Title: Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature.
Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1).
Title: Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS(1)).
Elevated neurotensin levels among obese adolescents may be related to emotion dysregulation and impulsivity: a cross-sectional, case-control study.
Title: Elevated neurotensin levels among obese adolescents may be related to emotion dysregulation and impulsivity: a cross-sectional, case-control study.
Neurotensin: a neuropeptide induced by hCG in the human and rat ovary during the periovulatory perioddagger.
Title: Neurotensin: a neuropeptide induced by hCG in the human and rat ovary during the periovulatory period†.
Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort.
Title: Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort.
Expression of neurotensin receptor-1 (NTS1) in primary breast tumors, cellular distribution, and association with clinical and biological factors.
Title: Expression of neurotensin receptor-1 (NTS(1)) in primary breast tumors, cellular distribution, and association with clinical and biological factors.
The Role of Central Neurotensin in Regulating Feeding and Body Weight.
Title: The Role of Central Neurotensin in Regulating Feeding and Body Weight.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurotensin/neuromedin N

Names: pro-neurotensin/neuromedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.