Appendix DClinical questions

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What is the diagnostic value of the history-taking and the physical examination in diagnosing chronic idiopathic constipation in newborns, infants and children?

What is the diagnostic value of the digital rectal examination in children with chronic idiopathic constipation?

What is the diagnostic value of the gastrointestinal endoscopy in children with chronic idiopathic constipation?

What is the prevalence of hypothyroidism and coeliac disease in children with chronic constipation?

What is the diagnostic value of the anorectal manometry in children with chronic idiopathic constipation?

What is the diagnostic value of plain abdominal radiography to diagnose chronic idiopathic constipation in children?

What is the diagnostic value of the rectal biopsy in children with chronic idiopathic constipation?

What is the diagnostic value of transit studies in children?

What is the diagnostic value of the abdominal ultrasound in children with chronic constipation?

What is the effectiveness of pharmacological and surgical intervention for disimpaction in children with chronic idiopathic constipation?

What is the clinical effectiveness of pharmacological interventions for ongoing treatment/maintenance in children with chronic idiopathic constipation?

What are the adverse effects of the medium- to long-term use of laxatives?

What is the effectiveness of the Antegrade Colonic Enema (ACE) procedure in children with chronic idiopathic constipation?

What is the clinical effectiveness of the following complementary therapies for ongoing treatment/maintenance in children with chronic idiopathic constipation?

  • abdominal massage
  • reflexology
  • hypnotherapy
  • osteopathy
  • cranial osteopathy
  • craniosacral therapy
  • homeopathy.

What is the effectiveness of the information, support and advice that children/young people and their parents / carers are given regarding the treatment/management of idiopathic constipation?

What is the clinical effectiveness of the following for ongoing treatment/maintenance in children with chronic idiopathic constipation?

  • increasing physical activity
  • dietary modifications
  • increasing fluid intake
  • excluding cows' and goats' milk protein from diet.

What is the clinical effectiveness of psychological and behavioural interventions in addition to laxatives for ongoing treatment/maintenance in children with chronic idiopathic constipation?