NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|754502064|ref|NP_001291647|]
View 

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 3 [Homo sapiens]

Protein Classification

PTEN_C2 domain-containing protein( domain architecture ID 10564237)

PTEN_C2 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTEN_C2 pfam10409
C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key ...
 1-152 7.20e-38

C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.


:

Pssm-ID: 463081  Cd Length: 133  Bit Score: 127.78  E-value: 7.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502064    1 MMFETIPMF-SGGTCNPQFVVCQLKVKI---YSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHF 76
Cdd:pfam10409  11 IILHGIPNFkSGGGCRPYIRIYQNKKKVfstSGKYKKLKEYQQDDCVILFPKGIPVQGDVLVEFYHKGSDLLSEEKMFRF 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754502064   77 WVNTFFIPgpeetsekvengslcdqeidsicsieradndkeYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTK 152
Cdd:pfam10409  91 WFNTSFIE---------------------------------DNTLTLPKNELDKADKDKKDKRFPKDFKVELLFSE 133
 
Name Accession Description Interval E-value
PTEN_C2 pfam10409
C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key ...
 1-152 7.20e-38

C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.


Pssm-ID: 463081  Cd Length: 133  Bit Score: 127.78  E-value: 7.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502064    1 MMFETIPMF-SGGTCNPQFVVCQLKVKI---YSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHF 76
Cdd:pfam10409  11 IILHGIPNFkSGGGCRPYIRIYQNKKKVfstSGKYKKLKEYQQDDCVILFPKGIPVQGDVLVEFYHKGSDLLSEEKMFRF 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754502064   77 WVNTFFIPgpeetsekvengslcdqeidsicsieradndkeYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTK 152
Cdd:pfam10409  91 WFNTSFIE---------------------------------DNTLTLPKNELDKADKDKKDKRFPKDFKVELLFSE 133
 
Name Accession Description Interval E-value
PTEN_C2 pfam10409
C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key ...
 1-152 7.20e-38

C2 domain of PTEN tumour-suppressor protein; This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.


Pssm-ID: 463081  Cd Length: 133  Bit Score: 127.78  E-value: 7.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502064    1 MMFETIPMF-SGGTCNPQFVVCQLKVKI---YSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHF 76
Cdd:pfam10409  11 IILHGIPNFkSGGGCRPYIRIYQNKKKVfstSGKYKKLKEYQQDDCVILFPKGIPVQGDVLVEFYHKGSDLLSEEKMFRF 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754502064   77 WVNTFFIPgpeetsekvengslcdqeidsicsieradndkeYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTK 152
Cdd:pfam10409  91 WFNTSFIE---------------------------------DNTLTLPKNELDKADKDKKDKRFPKDFKVELLFSE 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH