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Stephen Altschul's Research Group
Stephen Altschul, PhD
NCBI, NLM, NIH
Computational Biology Branch
Building 38A, Room 6AN605
Bethesda, MD 20894

Tel: 301-435-7803
Fax: 301-480-2288
Email: altschul@ncbi.nlm.nih.gov

PhD, Massachusetts Institute of Technology,
   Cambridge, MA, 1987
AB, Harvard College,
   Cambridge, MA, 1979
Research Interests:

  • Sequence alignment algorithms
  • Statistics of sequence comparison
  • Measures of sequence similarity

Links to Additional Resources:

Yu Y-K, Wootton JC, Altschul SF. The compositional adjustment of amino acid substitution matrices. Proc Natl Acad Sci USA. 2003 Dec 23;100(26):15688-93.

Mammalian Gene Collection Program Team. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA. 2002 Dec 24;99(26):16899-903.

Schaffer AA, Aravind L, Madden TL, Shavirin S, Spouge JL, Wolf YI, Koonin EV, Altschul SF. Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res. 2001 Jul 15;29(14):2994-3005.

Altschul SF, Bundschuh R, Olsen R, Hwa T. The estimation of statistical parameters for local alignment score distributions. Nucleic Acids Res. 2001 Jan 15;29:351-361.

Lash AE, Tolstoshev CM, Wagner L, Schuler GD, Strausberg RL, Riggins GJ, Altschul SF. SAGEmap: A public gene expression resource Genome Res. 2000 Jul;10:1051-1060.

Schaffer AA, Wolf YI, Koonin EV, Aravind L, Altschul SF. IMPALA: matching a protein sequence against a collection of PSI-BLAST- onstructed position- specific score matrices. Bioinformatics. 1999 Dec;15:1000-1011.

Zhang Z, Schaffer AA, Miller W, Madden TL, Lipman DJ, Koonin EV, Altschul SF. Protein sequence similarity searches using patterns as seeds. Nucleic Acids Res. 1998 Sep 1;26:3986-3990.

Altschul SF, Madden TL, Schaffer, AA, Zhang Z, Miller W, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997 Sep 1;25(17): 3389-3402.

ISI Web of Knowledge. ISI HighlyCited.com Researcher Profile: Stephen F. Altschul.


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Revised: April 28, 2004.


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Group Members (Click on link to send Email):

Alejandro Schaffer